Course Description

 

Learn the basic facts and principles of toxicology and use problems and exercises to enhance your knowledge. Learn how chemicals and chemical releases impact human health or the environment, and how this impact will affect your regulatory compliance programs under the various EH&S laws.

Course Objective

 

·         You will learn toxicology's key definitions and terminology

·         You'll learn what factors determine the impact toxics have on the body, how metabolism affects toxicity, and the various types of carcinogens and how they react within the body

·         You'll understand which chemicals cause respiratory abnormalities

·         Learn how to determine which exposure pathways are most likely to result in chronic intake

·         Learn new approaches and strategies for risk-based corrective action

Who Should attend?

 

• Beginning industrial hygienists

• Occupational safety practitioners

• Environmental health practitioners

• Safety professionals

• Nurses

• Plant managers

• Supervisory personnel

• Union representatives

• Personnel managers

• Research chemists

• Physicians

Course Outline

 

DAY 1

Understanding the General Principles of Toxicology:

This opening session will lay the basic framework upon which the remainder of the course is built. It will begin by answering

the fundamental questions: What exactly is toxicology? Upon what sciences is it based? Then the course will move into the

terminology and key definitions you’ll need to know, as well as the key principles

you’ll need to understand.

Understanding the General Principles of Toxicology:

You’ll learn what factors determine the impact toxins have on the body and the dose-response relationship. Discover how the

absorption, distribution, metabolism, and excretion of chemicals affect toxicity

(toxicokinetics).

DAY 2

Reproductive Toxicity and Carcinogenesis:

Examine the effects toxic substances can have on the reproductive process and the likelihood of their causing cancer. Learn

what defects and abnormalities are likely to occur during various stages of fetal and embryonic development. Learn about

genetic disorders that can occur. Discuss the various types of carcinogens, how they react within the body to form cancers,

and how the resulting hazards are categorized.

How Chemicals Impact the Liver, Kidneys, Blood, and Immune System:

Serious consequences occur as a result of exposure to toxic chemicals. Damage to the liver, kidneys, blood, and immune

system are common. Review the functions of these organs and systems and find out what effects toxins have on them. You

will also learn what tests are used to assess the extent of damage caused by the

chemicals.

Adjourn

DAY 3

How Chemicals Impact the Skin, Lungs, Eyes, and Nervous System:

Review the important functions of the skin, lungs, eyes, and nervous system and learn the responses that occur when they

are exposed to toxins. What chemicals cause respiratory abnormalities? What chemicals are known neurotoxicants? What

substances cause toxic responses in the eyes?

Review of Toxicity of Selected Chemicals:

You’ll focus on the toxicity of several widely distributed chemicals including dioxins, metals, and chlorinated hydrocarbons.

Discuss, in layperson’s terms, the latest scientific findings on dose and response profiles.

DAY 4

Role of Toxicology in Risk Assessment:

Risk assessments are crucial tools in identifying how a chemical release will impact human health or the environment. Look

At how toxicity information is used in determining these risks. Find out what agencies and key legislation is driving risk

Assessment. Learn the various types of risk assessment, the exposure pathways most likely to result in chronic intake, how

you can use risk assessments to determine appropriate exposures within facilities, and cleanup standards for contaminated

Sites.

DAY 5

Risk-Based Corrective Action:

You’ll learn new approaches for risk-based corrective action, including applications of the ASTM model for petroleum release

sites and new ASTM standards for non-petroleum release sites. You’ll also discuss

extensions of these models to other sites.

Adjourn